IGN has posted an interview with Civilization IV's producer Barry Caudill, who provides more detail on the what's changed since the last Civilization title
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3D engine
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still covers the 4000 BC to 2050 AD timeframe
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revamped movement and combat mechanics
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animated, dynamic landscapes (moving cows, flowing rivers)
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18 civilizations
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better AI
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additional resources for trade
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new "religion" system for theocratic governments
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addition of the touchy (but historically accurate) topics of slavery and emancipation
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elimination of terrorism options (poisoning a city's water supply has become a taboo topic since the last Civ game)
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the most moddable version of Civilization ever
Visit the folks over at CivFanatics.com for great commentary and analysis on the IGN interview linked below.
