Ray Almeda, of AMN, sat down with the Spore creator yesterday evening and asked if gamers would be able to play the upcoming title on the DS (and Sony's handheld...thing), with which he responded "Yes...definitely."
Will's past attempts in gaming have been nothing but gold, with his Simcity and The Sims franchises being easily accessible to people in all walks of life (heck, some of my assignments back in middle school were to build fully-functioning cities in Simcity) and pushed the envelope of conventional game design. It's no wonder that so many eyes are on him and his upcoming project. We just hope Spore on the DS will be WiFi compatible in some way.
Spore is currently slated for a 2007 release.
[Update: Definitely fixed a typo.]