Instead, multiplayer is limited to local system play. A flyer from New York Comic Con (via GoNintendo) shows the game will include competitive and cooperative modes -- although no other details were revealed.
While Nintendo Wi-Fi Connection won't be used for multiplayer, it will allow players to communicate and interact with their friends. For example, you'll be able to share favorite locations, chat live through in-game instant messaging, and trade in-game items. Stats can also be uploaded to Rockstar's Social Club site. Through the Social Club, Rockstar is promising "special contests, events, and promotions," although what those will entail is still unclear at this moment.