If there's one thing this Assassin's Creed: Brotherhood trailer proves, it's the mercenary is good at killing. Whether through a discrete stab to the gut or a long-distance headshot with his wrist-mounted pistol, nobody can question his ability to generate death -- that and his sweet Renaissance-period mullet, of course.
Rather than using money earned to bolster a villa, you'll fix up Rome itself, which will change Ezio's social standing, unlock missions and curry favor with various factions. The release promises collaboration with Da Vinci, Machiavelli, and Caterina Sforza, and describes new "secret weapons." Ubi is throwing in poison darts, parachutes, hidden blades and guns, not to mention an "advanced flying machine" -- which is presumably useful in more than a single mission this time.
Multiplayer -- developed by Ubisoft Annecy, who created the online component of Splinter Cell: Chaos Theory -- is said to feature "multiple authentic character classes" (presumably the characters seen in the gallery below) each of whom will use "signature weapons and killing moves."