The most obvious guess would be it's the name of the new Hitman game, in production under IO supervision at the Square Enix studio in Montreal. Considering Hitman: Absolution won't be ready until sometime in 2012, it'd be surprising if Square had already filed trademarks on the next installment.
Hitman: Profession could also be some kind of transmedia tie-in, mimicing Ubisoft's Assassin's Creed model and creating experiences -- loosely tied to the core game -- covering comics, iOS and Facebook. Like we said: speculation!
