Naughty Dog is looking to make The Last of Us
the most realistic fungal-zombie-apocalypse game ever created. Game director Bruce Straley and creative director Neil Druckmann let slip a few details about combat mechanics in a video interview with Game Informer: Health will not automatically regenerate; Ellie, your AI companion, will be intelligent enough to throw bricks and other materials at your enemies, and she won't break your "stealth" mode; and it may include Uncharted-esque playable cinematics, but in more intimate environments.
Straley and Druckmann discuss combat moments as part strategy, part shooter, and say they're infusing the title with realistic reactions from NPCs and the protagonist alike. Watch the entire interview here