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FoxDie (9 of 17)
FoxDie
Nano machines play a big role in the MGS series. They're used to enhance character's abilities (which may account for some of the supernatural happenings) and, in MGS4, "sync up" the actions of every soldier on the battlefield.
In MGS1, Dr. Naomi Hunter designs a nano machine virus called FoxDie, which is injected into all of FOXHOUNDS's members and Solid Snake. FoxDie is meant to kill anyone who has been genetically enhanced with Big Boss' DNA (basically all of the game's enemy soldiers, FOXHOUND members, Liquid Snake, and Solid Snake) when triggered.
Naomi injects Solid Snake with FoxDie and sets its activation time/date to a random "wildcard" figure purely out of revenge; she believes Snake killed her brother. The game ends with Hunter telling Snake to "live life," because neither she nor he know when it will go "boom."
In MGS4, FoxDie has been re-engineered by Naomi to provide Liquid Ocelot with control over every soldier on the battlefield who carries it in their blood - and that's almost everyone.

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